Endocrine Abstracts

Introduction: Prader Willi Syndrome (PWS) is a genetic syndrome characterized by hyperphagia, morbid obesity, and many other endocrine alterations. PWS subjects present higher ghrelin levels. The cause of this increase as well as the modulation of ghrelin secretion at fasting and feeding in relation to other metabolic parameters in PWS is largely unknown. It has also been demonstrated that many ghrelin gene (GHRL) polymorphisms are associated with obesity, type 2 diabetes, and...